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Related Experiment Videos

Sulfasalazine improves psoriasis. A double-blind analysis.

A K Gupta1, C N Ellis, M T Siegel

  • 1Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314.

Archives of Dermatology
|April 1, 1990
PubMed
Summary

Sulfasalazine demonstrates significant efficacy in treating moderate-to-severe psoriasis, with over 80% of patients showing improvement. This oral therapy offers a viable option for widespread psoriasis when other treatments are unsuitable.

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Age and gender differences in the impact of psoriasis on quality of life.

International journal of dermatology·1995

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Psoriasis is a chronic inflammatory skin condition requiring effective systemic therapies.
  • Current systemic treatments like methotrexate, etretinate, and psoralen plus UV-A carry significant risks or limitations.
  • Sulfasalazine offers a potential oral treatment option for moderate-to-severe psoriasis.

Purpose of the Study:

  • To evaluate the efficacy and safety of sulfasalazine for moderate-to-severe psoriasis.
  • To compare sulfasalazine's effectiveness against a placebo in a double-blind trial.

Main Methods:

  • An 8-week double-blind, placebo-controlled trial involving 23 patients on sulfasalazine and 27 on placebo.
  • Patients receiving sulfasalazine continued for an additional 4 weeks in an open-label phase.
  • Adverse events and patient improvement were assessed throughout the study.

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Main Results:

  • At 8 weeks, 41% of sulfasalazine patients had marked improvement, 41% moderate, and 18% minimal.
  • Only 1 placebo patient showed moderate improvement; others had minimal change or worsening.
  • In the open-label phase, 57% of patients achieved marked improvement after 4 additional weeks.

Conclusions:

  • Sulfasalazine is an effective oral treatment for moderate-to-severe psoriasis.
  • The drug exhibits a favorable safety profile with a low incidence of severe side effects.
  • Sulfasalazine is a suitable therapeutic consideration for patients with widespread psoriasis unsuitable for other systemic or topical treatments.