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A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
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[Intercellular adhesion molecules sICAM-1, sICAM-2, sICAM-3 and IFNgamma in neuroborreliosis and tick-borne

Małgorzata Pietruczuk1, Adam Pietruczuk, Sławomir Pancewicz

  • 1Oddział Internistyczno-Kardiologiczny SP ZOZ w Sokółce.

Przeglad Epidemiologiczny
|August 17, 2006
PubMed
Abstract

Insights

Soluble intercellular adhesion molecules and IFNgamma are elevated in tick-borne encephalitis (TBE) and Lyme meningitis. These markers suggest their role in the pathogenesis of these neuroinfections.

Area of Science:

  • Neuroimmunology
  • Infectious Diseases

Background:

  • Tick-borne encephalitis (TBE) and Lyme neuroborreliosis are significant neuroinfections.
  • Intercellular adhesion molecules (ICAMs) and cytokines are implicated in inflammatory responses.

Purpose of the Study:

  • To evaluate serum and CSF levels of soluble ICAM-1, ICAM-2, ICAM-3, and IFNgamma in TBE and neuroborreliosis patients.
  • To assess changes in these markers before and after treatment.

Main Methods:

  • Study included 40 patients: 20 with TBE meningitis and 20 with Lyme meningitis.
  • Serum and CSF levels of ICAMs and IFNgamma were measured using ELISA.
  • Measurements were taken pre- and post-treatment.

Main Results:

  • Pre-treatment, ICAMs and IFNgamma were significantly higher in both groups compared to controls (except sICAM-2 in TBE serum).
  • Post-treatment, TBE serum markers normalized, while CSF levels decreased but remained elevated.
  • Neuroborreliosis patients showed decreased serum and CSF markers post-treatment, with stable sICAM-1 and sICAM-2 serum levels.

Conclusions:

  • The findings confirm the involvement of intercellular adhesion molecules in the pathogenesis of TBE and neuroborreliosis.
  • These molecules play a role in the inflammatory processes of viral and bacterial neuroinfections.

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