Related Experiment Video

Updated: Aug 6, 2026

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization
11:29

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Published on: July 10, 2017

[Interstitial telomere repeats as markers of evolutionary changes in the mammalian karyotype: human chromosome 2]

N V Vorob'ev, L S Biltueva, Iu L Orlov

    Biofizika
    |August 17, 2006
    PubMed

    More Related Videos

    Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells09:13

    Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells

    Published on: January 17, 2019

    Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers11:21

    Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers

    Published on: August 30, 2024

    Related Concept Videos

    Telomeres and Telomerase02:41

    Telomeres and Telomerase

    In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
    Replication in Eukaryotes02:31

    Replication in Eukaryotes

    Overview
    Replication in Eukaryotes01:29

    Replication in Eukaryotes

    In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
    Many Proteins Orchestrate Replication at the Origin
    Eukaryotic replication follows many of the same...
    Chromosome Structure02:40

    Chromosome Structure

    A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
    The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
    Telomeres consist of non-coding repetitive nucleotide...
    Synteny and Evolution02:31

    Synteny and Evolution

    John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
    Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral chromosome underwent...
    Karyotyping01:17

    Karyotyping

    Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...