Related Experiment Video

Updated: Aug 5, 2026

Creation of Abdominal Adhesions in Mice
06:44

Creation of Abdominal Adhesions in Mice

Published on: August 27, 2016

Peritoneal adhesions: pathogenesis, assessment and effects

M P Senthilkumar1, Jacob S Dreyer

  • 1Department of Surgery, Dumfries and Galloway Royal Infirmary, Dumfries, UK. sanskrity@hotmail.com

Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
|August 17, 2006
PubMed
Abstract

Insights

Peritoneal adhesions, a common surgical complication, can lead to serious issues like bowel obstruction and infertility. Prevention strategies are crucial for managing these lifelong risks.

Area of Science:

  • Surgical pathology
  • Gastroenterology
  • Reproductive medicine

Background:

  • Iatrogenic peritoneal adhesions are an increasing concern in modern surgery.
  • Understanding the pathogenesis and impact of adhesions is vital for surgeons.
  • Adhesions and their complications are frequently managed in clinical practice.

Purpose of the Study:

  • To review the etiopathogenesis, clinical spectrum, and effects of peritoneal adhesions.
  • To synthesize current knowledge on adhesion formation and consequences.

Main Methods:

  • Systematic literature search of Medline, Embase, and Cochrane controlled trials register (1966-2005).
  • Scrutiny of reference lists from key publications for additional relevant articles.

Main Results:

  • Adhesions form in over 75% of patients post-laparotomy.
  • Peritoneal trauma triggers an inflammatory response involving fibrin formation andolysis.
  • Adhesions cause significant healthcare burdens, including intestinal obstruction, infertility, and reoperation challenges.

Conclusions:

  • Peritoneal injury poses a lifelong risk of complications from adhesions.
  • Epidemiological data highlight the need for greater problem acknowledgement and preventive strategies.
  • While adhesiolysis aids in obstruction and infertility, its efficacy for chronic pain remains uncertain.

More Related Videos

Laparoscopic Common Bile Duct Exploration in Patients with a Previous History of Biliary Tract Surgery07:36

Laparoscopic Common Bile Duct Exploration in Patients with a Previous History of Biliary Tract Surgery

Published on: February 10, 2023

A Translational Surgical Porcine Model for Postoperative Intra-Abdominal Adhesion Formation03:47

A Translational Surgical Porcine Model for Postoperative Intra-Abdominal Adhesion Formation

Published on: March 13, 2026

Related Concept Videos

Peritoneum01:21

Peritoneum

The peritoneum is a vital membrane that lines the abdominal cavity and covers most of the organs within it. It plays a crucial role in protecting the organs, providing a smooth surface for their movement, and facilitating various physiological processes. Understanding the anatomy and function of the peritoneum is essential for comprehending the complexities of the abdominal region.
Anatomy of the Peritoneum
The peritoneum is divided into two layers: the parietal peritoneum and the visceral...
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Ascites01:19

Ascites

DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...