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Updated: Aug 6, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
Published on: December 13, 2019
[Doppler echocardiographic assessment of diastolic function of left ventricle]
Ivo Bozić1, Stojan Polić, Drago Rakić
1Klinika za unutrasnje bolesti. ibozic@kbsplit.hr
Insights
Diastolic dysfunction, an abnormality in heart relaxation, affects half of congestive heart failure patients without reduced ejection fraction. Echocardiography is key to assessing this common condition.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Background:
- Diastolic dysfunction is prevalent in congestive heart failure (CHF), often occurring without reduced ejection fraction (LVEF>50%).
- It involves impaired left ventricular relaxation or compliance, affecting diastolic filling.
- Conditions like hypertension and coronary artery disease frequently cause diastolic dysfunction.
Purpose of the Study:
- To review the clinical impact of echocardiographic methods in assessing diastolic dysfunction.
- To highlight the importance of understanding diastolic impairment in CHF.
Main Methods:
- Review of classic and recent echocardiographic contributions to diastology.
- Focus on noninvasive Doppler-echocardiographic assessment techniques.
Main Results:
- Diastolic dysfunction is common, even with preserved ejection fraction.
- Elevated left atrial pressures compensate for impaired filling.
- The severity of diastolic dysfunction correlates with symptom severity in CHF patients with reduced systolic function.
Conclusions:
- Accurate echocardiographic assessment of diastolic function is crucial for understanding and managing this condition.
- Diastolic dysfunction plays a significant role in the pathophysiology and symptomatology of CHF.
Abstract:
Approximately half of the patients with overt congestive heart failure (CHF) have diastolic dysfunction without reduced ejection fraction (LVEF>50%). Diastolic dysfunction is an abnormality in left ventricular myocardial relaxation and/or compliance that alters the ease with which blood is accepted into the left ventricle during diastole. Elevated pressures in the left atrium are compensatory, ensuring adequate filling. All patients with systolic dysfunction have concomitant diastolic dysfunction. Indeed, in patients with CHF and reduced systolic function the level of diastolic dysfunction influences the severity of symptoms. It is now clear that hypertension, coronary artery disease and other diseases and conditions commonly produce diastolic dysfunction in the absence of significant systolic dysfunction. Accurate noninvasive Doppler-echocardiographic assessment of the presence and severity of diastolic impairment is crucial to the broad application and understanding of this common condition. This review discusses the clinical impact of classic and recent echocardiographic contributions to the field of diastology.
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Normal Heart Sounds
S1 (First Heart Sound)-
S1 is made by the closure of the mitral and tricuspid valves (atrioventricular valves), marking the beginning of systole.
S2 (Second Heart Sound)-
S2 is made by the closure of the aortic and pulmonic valves (semilunar valves), marking the end of the systole.
