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[Enteropathy-type T-cell lymphoma with CD8 and CD56 expression].

Tsutomu Sato1, Takuya Matsunaga, Satoshi Iyama

  • 1Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|August 17, 2006
PubMed
Summary

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A rare case of enteropathy-type T-cell lymphoma (ETL) was diagnosed in a 54-year-old male. This patient lacked typical celiac disease markers, highlighting atypical presentations of ETL.

Area of Science:

  • Gastroenterology
  • Oncology
  • Immunology

Background:

  • Enteropathy-type T-cell lymphoma (ETL) is a rare gastrointestinal malignancy often associated with celiac disease.
  • Diagnosis typically involves identifying atypical lymphocytes in intestinal biopsies and confirming T-cell clonality.

Observation:

  • A 54-year-old male presented with abdominal pain and was found to have abdominal and retroperitoneal lymphadenopathies.
  • Endoscopy revealed a duodenal tumor with medium-sized atypical lymphocytes in biopsy specimens.
  • Immunohistochemical staining showed positivity for CD3, CD8, CD56, and CD103, with T-cell receptor gamma-chain gene rearrangement.

Findings:

  • The patient was diagnosed with enteropathy-type T-cell lymphoma (ETL).
  • Crucially, the patient did not exhibit the typical celiac disease indicators such as malabsorption or anti-gliadin antibodies.

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Implications:

  • This case underscores that enteropathy-type T-cell lymphoma can occur in the absence of classical celiac disease.
  • It highlights the importance of considering ETL in patients with unexplained gastrointestinal symptoms and lymphadenopathy, even without serological evidence of celiac disease.
  • Further research may be needed to understand the diverse etiologies and diagnostic challenges of ETL.