Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gating charge transfer due to fixed ionizable sites.

D T Edmonds1

  • 1Clarendon Laboratory, Oxford, United Kingdom.

European Biophysics Journal : EBJ
|January 1, 1990
PubMed
Summary

This study proposes a new source for ion channel gating charge transfer, involving proton migration across membranes. This alternative mechanism offers new insights into ion channel gating dynamics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The behaviour of ions in narrow water-filled pores.

Bioscience reports·1999
Same author

A novel explanation for fluctuations of ion current through narrow pores.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·1997
Same author

A sensitive optically detected magnetic compass for animals.

Proceedings. Biological sciences·1996
Same author

Linear electric traction as an alternative model of the actin/myosin motor.

Journal of theoretical biology·1996
Same author

Rapid switching of ion current in narrow pores: implications for biological ion channels.

Proceedings. Biological sciences·1993
Same author

Correlated ion flux through parallel pores: application to channel subconductance states.

The Journal of membrane biology·1993

Area of Science:

  • Biophysics
  • Molecular Biology
  • Electrochemistry

Background:

  • Ion channel gating is crucial for cellular electrical signaling.
  • Gating charge transfer is a key measurable event during channel opening.
  • Current models attribute gating charge solely to moving charged groups.

Purpose of the Study:

  • To propose an alternative origin for a component of ion channel gating charge transfer.
  • To explore the role of proton migration in ion channel gating.
  • To describe the characteristics of this novel gating charge transfer mechanism.

Main Methods:

  • Theoretical modeling of charge transfer mechanisms.
  • Analysis of proton migration across membranes.
  • Simulation of ionizable sites responding to environmental and voltage changes.

Main Results:

  • A novel component of gating charge transfer may originate from ionizable sites.
  • Proton migration across the membrane contributes to charge transfer.
  • Charge state changes can be triggered by dielectric environment shifts or transmembrane voltage.

Conclusions:

  • Ionizable sites changing charge state offer an alternative explanation for gating charge transfer.
  • Proton migration is a significant factor in this proposed mechanism.
  • This model predicts unique characteristics for a novel component of gating charge transfer.

Related Experiment Videos