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Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
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Transient hyperphosphatasemia after pediatric liver transplantation

Cigdem Arikan1, Mehmet Tayyip Arslan, Murat Kilic

  • 1Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University School of Medicine, Organ Transplantation and Research Center, Izmir, Turkey. cigdem.arikan@ege.edu.tr

Pediatrics International : Official Journal of the Japan Pediatric Society
|August 17, 2006
PubMed

Insights

Transient hyperphosphatasemia, a temporary increase in alkaline phosphatase (ALP), occurred in 2.8% of pediatric liver transplant recipients. This benign condition, often linked to diarrhea, does not indicate significant underlying pathology.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Transplantation Medicine

Background:

  • Transient hyperphosphatasemia involves temporary elevations in serum alkaline phosphatase (ALP) activity in young children.
  • Limited data exists on the incidence of this condition in pediatric liver transplant recipients.

Purpose of the Study:

  • To determine the rate of transient hyperphosphatasemia in pediatric liver transplant recipients.
  • To characterize the clinical presentation and outcomes of this condition in this specific patient population.

Main Methods:

  • Retrospective analysis of medical records from 70 pediatric liver transplant recipients.
  • Data collected from Ege University Organ Transplantation and Research Center between January 1998 and January 2005.

Main Results:

  • Transient hyperphosphatasemia was observed in 2.8% (2 out of 70) of patients.
  • Both cases experienced diarrheal episodes preceding peak ALP activity; one was linked to Rotavirus.
  • ALP levels normalized within 4 to 18 months, with stable graft function.

Conclusions:

  • Elevated ALP levels in pediatric liver transplant recipients can be transient and benign.
  • Awareness of transient hyperphosphatasemia can prevent unnecessary investigations and interventions.
Abstract

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