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Updated: Aug 6, 2026

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
Published on: March 23, 2022
Attentional bias predicts heroin relapse following treatment
Marlies A E Marissen1, Ingmar H A Franken, Andrew J Waters
1Parnassia Addiction Research Centre, Parnassia Mental Health Institute, Arie de Jongstraat 25, 2553 RK The Hague, the Netherlands. m.marissen@psyq.nl
Aims:
Previous studies have shown that abstinent heroin addicts exhibit an attentional bias to heroin-related stimuli. It has been suggested that attentional bias may represent a vulnerability to relapse into drug use. In the present study, the predictive value of pre-treatment attentional bias on relapse was examined in a population of abstinent heroin addicts. Further, the effect of cue exposure therapy (CET) on attentional bias was studied.
Design:
Participants were assigned randomly to receive nine sessions of CET or placebo psychotherapy.
Setting:
An in-patient drug abuse treatment setting.
Participants:
Abstinent heroin-dependent patients.
Measurements:
Participants completed the emotional Stroop task both before and after completing treatment.
Findings:
Pre-treatment attentional bias predicted relapse at 3-month follow-up, even when controlling for self-reported cravings at the test session. Further, attentional bias was reduced in both groups after therapy, independent of treatment condition.
Conclusions:
Attentional bias may tap an important component of drug dependence as it is a predictor of opiate relapse. However, CET does not specifically reduce attentional bias.
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