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Related Experiment Videos

Evolutionary constraints on yeast protein size.

Jonas Warringer1, Anders Blomberg

  • 1Department of Cell and Molecular Biology, Lundberg Laboratory, Göteborg University Medicinaregatan 9c, 41390 Göteborg, Sweden. jonas.warringer@gmm.gu.se

BMC Evolutionary Biology
|August 17, 2006
PubMed
Summary

In yeast, highly expressed proteins are smaller due to biosynthetic cost. Protein size is influenced by biochemical activity and protein connectivity, but not phenotypic pleiotropy.

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Area of Science:

  • Molecular Biology
  • Evolutionary Biology
  • Bioinformatics

Background:

  • Proteins exhibit wide size variation despite evolutionary pressure for genome reduction.
  • Investigated evolutionary forces shaping protein size in Saccharomyces cerevisiae.

Purpose of the Study:

  • To understand the evolutionary pressures influencing protein size in yeast.
  • To correlate protein size with expression, interactions, evolution rate, and biochemical function.

Main Methods:

  • System-wide bioinformatics approach using yeast protein data.
  • Compared protein size with experimental data on expression, pleiotropy, interactions, evolutionary rate, and biochemical classification.

Main Results:

  • Highly expressed proteins are smaller (biosynthetic cost hypothesis).

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  • Large proteins have more interactions, suggesting positive selection for connectivity.
  • Biochemical activity strongly influences protein size; biological process has minimal impact.

    • Conclusions:

    • Yeast protein size inversely correlates with expression levels.
    • Protein connectivity and biochemical activity are key factors affecting protein size.
    • Phenotypic pleiotropy does not significantly impact protein size.