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Evaluating preference weights for the Asthma Symptom Utility Index (ASUI) across countries
Emuella M Flood1, Erwin De Cock, Ann-Christin Mörk
1Center for Health Outcomes Research, United BioSource Corporation, Bethesda, MD, United States. emuella.flood@unitedbiosource.com
Health and Quality of Life Outcomes
|August 17, 2006
Summary
The Asthma Symptom Utility Index (ASUI) shows generalizable utility across European countries, despite minor differences in preference weights. This supports its use in international asthma clinical trials and cost-effectiveness studies.
Area of Science:
- Health Economics
- Clinical Outcomes Research
- Respiratory Medicine
Background:
- The Asthma Symptom Utility Index (ASUI) is a key measure in US asthma research.
- Its generalizability across countries is not well established.
Purpose of the Study:
- To evaluate ASUI preference weights in European populations.
- To determine if the US-derived ASUI utility function is applicable internationally.
Main Methods:
- Collected data from 90 asthma patients in Italy, France, and the UK.
- Utilized Asthma Control Questionnaire, Asthma Quality of Life Questionnaire, and ASUI.
- Assessed health state preferences via visual analogue scale (VAS) and standard gamble (SG).
Main Results:
- Significant cross-country differences observed in mean VAS scores for multi-symptom states.
- Statistically significant differences in SG utility scores between the US and European countries for specific symptom combinations.
- While country-specific utility functions varied slightly, algorithms maintained strong correlations and similar patient severity rankings.
Conclusions:
- The ASUI demonstrates potential as a complementary patient-reported outcome in international clinical studies.
- Its utility in cost-effectiveness analyses for comparing asthma treatments is supported.
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