Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Remission and relapse in psychosis: operational definitions based on case-note data.

Paul E Bebbington1, Tom Craig, Philippa Garety

  • 1Royal Free & University College London Medical School, UCL - Department of Mental Health Sciences (Bloomsbury Campus), London, UK. P.Bebbington@ucl.ac.uk

Psychological Medicine
|August 17, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Youth Mental Health in Vulnerable Communities: Barriers, Facilitators, and Place-Based Solutions-A Situational Analysis from England's Southeast Coast.

Journal of prevention (2022)·2026
Same author

"We Are Humans, and We Are People" - A Thematic Analysis Exploring the Disclosure and Help-Seeking Experiences of Young People Who Experience Voice-Hearing Within Mental Health Services in the UK.

Clinical child psychology and psychiatry·2025
Same author

Are measures of voice hearing distinct from measures of emotional states, recovery and well-being? A factor analysis study.

PloS one·2025
Same author

Weaving knowledge systems to eradicate drinking water crises in First Nations across Canada.

Journal of water and health·2025
Same author

Team-based motivational engagement intervention in young people with first-episode psychosis: the EYE-2 cluster RCT with economic and process evaluation.

Health and social care delivery research·2025
Same author

Health morbidities in carers with experience of domestic violence and abuse.

Social psychiatry and psychiatric epidemiology·2025

This study developed a reliable and valid case-note method for assessing psychosis relapse, crucial for outcome prediction when hospital readmission is no longer feasible. The technique offers objective, blind evaluation of remission and relapse in clinical research.

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • Traditional outcome indicators for psychosis, such as hospital readmission, are no longer reliable.
  • Objective, blind, reliable, and valid methods are needed to assess relapse in psychosis research.
  • This study introduces a novel case-note-based technique for evaluating psychosis remission and relapse.

Purpose of the Study:

  • To describe and validate a new method for assessing remission and relapse in psychosis using routine clinical case notes.
  • To evaluate the reliability and validity of this case-note assessment technique.

Main Methods:

  • A case-note review method was developed for the Lambeth Early Onset (LEO) study.
  • Operational definitions for remission and relapse were used to enable blind assessment.

Related Experiment Videos

  • Reliability was assessed for the identification and timing of remission/relapse.
  • Validity was assessed using PANSS ratings at 6 and 18 months.

    • Main Results:

    • The technique demonstrated moderate to good reliability for identifying remission (kappa 0.56–0.82) and relapse (kappa 0.57–0.71).
    • High intra-class correlations were found for time to remission and relapse.
    • Remission/relapse status was strongly related to independent PANSS ratings.
    • Raters could not reliably guess participants' group allocation, supporting blinding.

    Conclusions:

    • The case-note assessment method is reliable (moderate to good) and valid (good) for evaluating remission and relapse in psychosis.
    • This technique provides a timely and useful tool for psychosis research.
    • Consensus ratings between clinicians are recommended over individual ratings for improved reliability.