Upper urinary tract transitional cell carcinoma: recurrence rate after percutaneous endoscopic resection
Morgan Rouprêt1, Olivier Traxer, Mohamed Tligui
1Department of Urology, Groupe Hospitalo-Universitaire EST, Pitié-Tenon, Assistance Publique-Hôpitaux de Paris (AP-HP), University Paris VI, Paris, France. mroupret@club-internet.fr
European Urology
|August 17, 2006
Summary
Percutaneous management offers a viable alternative for low-grade upper urinary tract transitional cell carcinoma (UUT-TCC). Long-term surveillance is crucial for patients treated with this approach.
Area of Science:
- Urology
- Oncology
- Nephrology
Background:
- Upper urinary tract transitional cell carcinoma (UUT-TCC) presents treatment challenges.
- Nephroureterectomy (NUT) is a standard but invasive treatment option.
- Conservative management strategies are being explored for select UUT-TCC cases.
Purpose of the Study:
- To evaluate the oncologic outcomes of percutaneous management for UUT-TCC in renal cavities.
- To compare percutaneous management with traditional treatments like NUT and ureteroscopy.
- To identify factors influencing recurrence and survival rates after percutaneous treatment.
Main Methods:
- Retrospective review of 24 patients with UUT-TCC treated percutaneously between 1989 and 2005.
- Data collected included patient demographics, tumor characteristics, surgical details, complications, and follow-up data.
- Oncologic outcomes, including recurrence and survival rates, were assessed.
Main Results:
- The study included 24 patients with a median age of 70 years.
- Tumor locations included the renal pelvis (11 patients) and caliceal system (13 patients), with a mean size of 1.8 cm.
- Eight patients (33.3%) experienced local recurrence, and five patients (20.8%) died, four from disease progression. 5-year disease-specific survival was 79.5%.
Conclusions:
- Percutaneous management is a recommended alternative to NUT or ureteroscopy for low-grade or superficial UUT-TCCs in renal cavities.
- Long-term post-surgical surveillance is essential for patients undergoing percutaneous management.
- Open NUT remains the gold standard for high-grade or invasive UUT-TCCs.
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