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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...

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Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
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Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

Understanding hematopoietic stem-cell microenvironments.

Zhixing Li1, Linheng Li

  • 1Stowers Institute for Medical Research, Kansas City, MO 64110, USA. zhl@towers-institute.org

Trends in Biochemical Sciences
|August 17, 2006
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cell (HSC) research focuses on the stem cell niche. This review covers osteoblastic and vascular niches regulating HSCs, with implications for cancer research and clinical applications.

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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Cancer Biology

Background:

  • Adult mammalian stem cell research often uses the hematopoietic system as a model.
  • Recent discoveries have enhanced understanding of the microenvironment (niche) regulating hematopoietic stem cells (HSCs).

Purpose of the Study:

  • To summarize the molecular and cellular properties of osteoblastic and vascular niches.
  • To review their role in regulating HSC maintenance, proliferation, differentiation, mobilization, and homing.
  • To highlight recent findings and the emerging study of niche activity in cancers.

Main Methods:

  • Literature review and synthesis of recent findings on HSC niches.
  • Focus on osteoblastic and vascular niche characteristics.
  • Exploration of signaling pathways involved in HSC regulation.

Main Results:

  • Detailed characterization of osteoblastic and vascular niches.
  • Elucidation of their roles in homeostatic regulation of HSC behavior.
  • Identification of trends in studying niche activity within cancer contexts.

Conclusions:

  • Understanding HSC niche components (location, cell type, signaling) offers insights into other stem cell systems.
  • Knowledge of HSC niches has potential benefits for clinical applications.
  • The study of niche activity in cancers is a significant emerging trend.