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Large cell neuroendocrine carcinoma of the ampulla of Vater
Eswaran Selvakumar1, Velayutham Vimalraj, Shanmugasundaram Rajendran
1Department of Pathology, Center for G.I.Bleeding & Division of Hepatobiliary Pancreatic Diseases, Government Stanley Medical College Hospital, the Tamilnadu Dr. M.G.R. Medical University, Chennai, Tamilnadu, India.
Background:
Neuroendocrine tumors of the ampulla of Vater are extremely rare, and few cases of large cell neuroendocrine carcinoma (LCNEC) of the ampulla have been reported.
Methods:
A 48-year-old male with obstructive jaundice was admitted to our hospital. On examination the patient was found to have a periampullary growth and subsequently underwent the Whipple's procedure.
Results:
Histopathological examination and immuno-histochemistry revealed features of LCNEC of the ampulla of Vater. The patient developed multiple liver metastases 6 months after Whipple's procedure.
Conclusion:
LCNEC of the ampulla of Vater is rare and highly aggressive, with a dismal prognosis.
