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Related Experiment Videos

Blood pressure and lower limb function in older persons.

Raj C Shah1, Robert S Wilson, Julia L Bienias

  • 1Department of Family Medicine, Rush Alzheimer's Disease Center, 710 South Paulina, Suite 8 North, Chicago, IL 60612, USA. Raj_C_Shah@rush.edu

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|August 17, 2006
PubMed
Summary

High systolic blood pressure (SBP) is linked to faster decline in lower limb function among older adults. This association persists even when considering other health factors, highlighting SBP as a key factor in mobility loss.

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Area of Science:

  • Gerontology
  • Cardiovascular Health
  • Neurology

Background:

  • Gait difficulties in the elderly are multifactorial and not fully understood.
  • Blood pressure (BP) is a potential contributing factor to age-related mobility issues.

Purpose of the Study:

  • To investigate the association between blood pressure and changes in lower limb function in older individuals.

Main Methods:

  • Recruited 888 older Catholic clergy members without baseline dementia or Parkinson's disease.
  • Measured BP, recorded vascular diseases and diabetes, assessed cognition, and inspected medications at baseline.
  • Assessed gait and balance annually using performance-based tasks to derive lower limb function.

Main Results:

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  • A 10 mmHg increase in systolic blood pressure (SBP) correlated with a significant decline in lower limb function (p=.011).
  • Individuals with SBP of 160 mmHg experienced 28.7% faster decline in lower limb function compared to those with SBP of 120 mmHg.
  • This association remained significant after adjusting for vascular diseases, diabetes, or cognition, but not after censoring stroke survivors.

    • Conclusions:

    • Systolic blood pressure may be associated with the decline of lower limb function in the elderly.
    • Findings suggest SBP management could be important for maintaining mobility in older adults.