Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1

Angelina Jane Mosley1, Kiran N Meekings, Corinna McCarthy

  • 1Department of Immunology, Wright Fleming Institute, Imperial College London, Norfolk Place, London, United Kingdom.

Blood
|August 17, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emergence of West African Human T-Lymphotropic Virus 1aC Subgroup, Brazilian Amazon.

Emerging infectious diseases·2026
Same author

Asymptomatic is not silent: proposal of HTLV-1-associated multiple inflammatory disease as an early neuroinflammatory state.

Expert review of anti-infective therapy·2026
Same author

Loss of HTLV-1-specific CD8<sup>+</sup> T-cell immunity in virus carriers predisposed to adult T-cell leukemia/lymphoma.

Blood neoplasia·2026
Same author

Pharmacological targeting of IRF4 as a therapeutic strategy for multiple myeloma.

Nature chemical biology·2026
Same author

Time to HIV rebound after infusion of long-acting broadly neutralising antibodies 3BNC117-LS and 10-1074-LS and analytical treatment interruption (the RIO trial): a double-blind, randomised, placebo-controlled trial.

The lancet. HIV·2026
Same author

Synthesis of N-Acetyl-D- and -L-Leucine-<sup>13</sup>C<sub>6</sub> Tool Compounds in Neurodegenerative Disease.

ChemMedChem·2026
Same journal

Decentralized Clinical Trials in Hematology: the Promise and the Peril.

Blood·2026
Same journal

How I Treat Chemotherapy-Induced Thrombocytopenia with Thrombopoietin Receptor Agonists.

Blood·2026
Same journal

The Chaos of Choice in Large B-cell Lymphoma: A Call to Harmonize First-line Trial Design.

Blood·2026
Same journal

Precision Transfusion Medicine in the Omics Era.

Blood·2026
Same journal

Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia.

Blood·2026
Same journal

Identifying steroid-refractory aGVHD before it happens.

Blood·2026
See all related articles

Histone deacetylase inhibitors (HDIs) increase human T-lymphotropic virus type-1 (HTLV-1) gene expression but paradoxically reduce the CD8(+) cell-mediated killing of infected cells. This suggests HDIs may impair cytotoxic T-cell surveillance of HTLV-1.

Area of Science:

  • Virology
  • Immunology
  • Epigenetics

Background:

  • Human T-lymphotropic virus type-1 (HTLV-1) provirus expression dynamics in vivo remain largely unknown.
  • Restricted HTLV-1 gene expression is hypothesized to contribute to viral persistence by evading CD8(+) T-cell immune responses.
  • Derepressing HTLV-1 gene expression could potentially enhance the clearance of infected cells by CD8(+) T-cells.

Purpose of the Study:

  • To test the hypothesis that increased HTLV-1 gene expression enhances CD8(+) cell-mediated lysis of HTLV-1-infected cells.
  • To investigate the role of histone deacetylase enzyme inhibitors (HDIs) in modulating HTLV-1 expression and T-cell responses.

Main Methods:

  • Utilized histone deacetylase enzyme inhibitors (HDIs) to induce histone hyperacetylation and increase HTLV-1 gene expression in naturally infected lymphocytes.

Related Experiment Videos

  • Assessed Tax expression levels and quantified CD8(+) cell-mediated lysis of HTLV-1-expressing cells ex vivo.
  • Investigated the potential role of the microtubule-associated HDAC6 enzyme in the observed effects.

    • Main Results:

    • HDIs doubled Tax expression in HTLV-1-infected lymphocytes after overnight culture.
    • Concurrently, the rate of CD8(+) cell-mediated lysis of Tax-expressing cells ex vivo was halved.
    • HDIs demonstrated an inhibitory effect on the CD8(+) cell-mediated lytic process, implicating HDAC6.

    Conclusions:

    • Derepression of HTLV-1 gene expression via HDIs does not enhance, but rather impairs, CD8(+) T-cell-mediated killing of infected cells.
    • HDIs may reduce the efficiency of cytotoxic T-lymphocyte (CTL) surveillance against HTLV-1 in vivo.
    • Caution is recommended regarding the use of HDIs in nonmalignant HTLV-1 infections due to potential negative impacts on T-cell immunity.