Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Tetrahedral irradiation protocol for microbeam radiation therapy.

Daniel N Slatkin¹

¹d.slatkin@sbcglobal.net

Physics in Medicine and Biology

|August 17, 2006

Summary

Optimizing microbeam radiation therapy (MRT) requires patient repositioning. This study details patient-gantry movements for pseudo-orthogonal cross-firing of lesions with minimal gantry tilt using parallel microplanar beams.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Iodine nanoparticles enhance radiotherapy of intracerebral human glioma in mice and increase efficacy of chemotherapy.

Scientific reports·2019

Same author

Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery.

International journal of nanomedicine·2018

Same author

Gold nanoparticle hyperthermia reduces radiotherapy dose.

Nanomedicine : nanotechnology, biology, and medicine·2014

Same author

Infrared-transparent gold nanoparticles converted by tumors to infrared absorbers cure tumors in mice by photothermal therapy.

PloS one·2014

Same author

Microlocalization of lipophilic porphyrins: non-toxic enhancers of boron neutron-capture therapy.

International journal of radiation biology·2013

Same author

Response of the rat spinal cord to X-ray microbeams.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2013

Area of Science:

Medical Physics
Radiation Oncology
Radiosurgery

Background:

Microbeam radiation therapy (MRT) offers potential for improved tumor control and reduced normal tissue toxicity.
Effective dose delivery in MRT often necessitates precise patient positioning and beam angles.
Current methods may require complex setups for achieving optimal beam configurations.

Purpose of the Study:

To describe patient-gantry movements for optimizing microbeam radiation therapy.
To enable pseudo-orthogonal cross-firing of lesions with multiple exposures.
To minimize patient-gantry tilting during repositioning for fixed beam arrays.

Main Methods:

Described optional patient-gantry movements.
Utilized a fixed, horizontally propagated array of vertical, parallel microplanar beams.
Investigated configurations for two, three, or four exposures.

Main Results:

The described movements facilitate pseudo-orthogonal cross-firing of lesions.
Minimal patient-gantry tilting is achieved during repositioning.
The method is compatible with a fixed horizontal beam array.

Conclusions:

The proposed patient-gantry movements enhance the feasibility of optimizing microbeam radiation therapy.
This technique allows for improved dose distribution through pseudo-orthogonal irradiation.
The approach simplifies achieving complex beam geometries in MRT.

Related Experiment Videos