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Related Experiment Videos

Differences in breast cancer mortality worldwide: unsolved problems.

Hugo E C Kesteloot1, Jianjun Zhang

  • 1Department of Epidemiology, K.U. Leuven, Leuven, Belgium. hugo.kesteloot@med.kuleuven.be

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
|August 17, 2006
PubMed
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Global breast cancer mortality shows significant correlations with other cancer mortality rates and high animal fat intake. These ecological findings suggest nutrition, particularly animal fat, may promote breast cancer worldwide.

Area of Science:

  • Epidemiology
  • Nutritional Science
  • Oncology

Background:

  • Breast cancer mortality rates vary significantly worldwide and have fluctuated between 1970 and 2000.
  • Lifestyle factors, particularly nutrition, have shown contradictory findings regarding their role in breast cancer.
  • Understanding global disparities in breast cancer mortality is crucial for public health initiatives.

Purpose of the Study:

  • To explore potential explanations for observed global differences in breast cancer mortality rates.
  • To investigate correlations between breast cancer mortality and other causes of mortality, including various cancers.
  • To examine the relationship between breast cancer mortality and dietary fat intake across different countries.

Main Methods:

  • Utilized worldwide mortality data from 47 countries (World Health Organization) for breast cancer and other causes of death.

Related Experiment Videos

  • Correlated mortality data with dietary intake, focusing on animal and vegetal fat consumption (Food and Agricultural Organization).
  • Employed multivariate regression analysis to identify significant independent predictors of breast cancer mortality.

    • Main Results:

    • Found highly significant positive correlations between breast cancer mortality and mortality from other cancers (colon, stomach) in both sexes, consistent over 40 years.
    • Observed highly significant positive correlations between breast cancer mortality and animal (saturated) fat intake over 30 years.
    • Multivariate regression identified colon cancer, prostate cancer, and total energy intake as significant factors, alongside animal fat.

    Conclusions:

    • Ecological data suggest that nutritional factors, especially animal fat consumption, are significant contributors to global breast cancer mortality.
    • These findings contrast with results from most cohort studies, highlighting a need to reconcile ecological and individual-level data.
    • Further research with more refined and standardized dietary data is necessary to clarify the complex relationship between diet, lifestyle, and breast cancer mortality.