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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Seizures and encephalopathy as the presenting sign of viral gastroenteritis
1The Hospital for Sick Children, Toronto, Ontario, Canada. michael.weinstein@sickkids.ca
Insights
Encephalopathy is a common sign in hospitalized children with viral gastroenteritis, often presenting as seizures. While outcomes are good, it increases hospital stay and testing.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Gastroenterology
Background:
- Viral gastroenteritis is a common cause of hospitalization in children.
- Encephalopathy is a serious neurological complication that can occur in children.
Observation:
- This study investigated the incidence, characteristics, and outcomes of encephalopathy in children hospitalized with viral gastroenteritis.
- A retrospective chart review identified 181 children with viral gastroenteritis, of whom 13 (7.2%) presented with encephalopathy.
- Encephalopathy presentations included febrile seizures, afebrile seizures, and altered consciousness.
Findings:
- Cases and controls did not differ significantly in age or temperature.
- Children with encephalopathy had a significantly longer hospital stay (7 vs. 4.3 days).
- All children with encephalopathy recovered without long-term sequelae.
Implications:
- Encephalopathy, including nonconvulsive and afebrile seizures, is a notable complication of viral gastroenteritis in children.
- Prompt recognition and management are crucial, despite the generally good prognosis.
- Increased diagnostic workups and prolonged hospitalizations are associated with encephalopathy in this population.
Objectives:
To determine the incidence, nature, and outcome of encephalopathy associated with viral gastroenteritis in hospitalized children.
Methods:
Retrospective chart review of all children during a 4-year period with viral gastroenteritis identified by International Classification of Diseases, Ninth Revision, Clinical Modification/International Classification of Diseases, Tenth Revision (ICD-9-CM/ICD-10) codes. Children with encephalopathy were defined as cases; the remainder served as controls.
Results:
Thirteen (7.2%) of 181 children presented with encephalopathy (typical febrile seizures, 4; atypical febrile seizures, 4; afebrile seizures, 3; with alteration in level of consciousness alone, 2). Between cases and controls, the mean age (17.4 vs. 14.9 months, respectively) and temperature (38.4 degrees C vs. 38.5 degrees C, respectively) were not significantly different (mean age, P = 0.52; temperature, P = 0.61). The mean length of hospital stay was longer in children with encephalopathy (7 vs. 4.3 days; P = 0.03). All children recovered without sequelae.
Conclusions:
Encephalopathy, including afebrile seizures and nonconvulsive encephalopathy, is a relatively common presenting sign of acute viral gastrointestinal tract infection in hospitalized children, has a good outcome, but is associated with increased diagnostic testing and length of stay.
Related Concept Videos
Encephalitis l: Introduction
Hepatic Encephalopathy
Encephalitis ll: Pathophysiology
Viral Meningitis
Seizures l: Introduction
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:

