Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MicroRNAs: expression, avoidance and subversion by vertebrate viruses.

Peter Sarnow1, Catherine L Jopling, Kara L Norman

  • 1Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94301, USA. psarnow@stanford.edu

Nature Reviews. Microbiology
|August 17, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct virus-derived circular RNA molecule influences host response during SARS-CoV-2 infection.

bioRxiv : the preprint server for biology·2026
Same author

Invertebrate miRNA pva-small RNA-11881/pva-miR-11881 as a potential RNA-based therapeutic against white spot syndrome virus in infected shrimp.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations.

Molecular therapy. Nucleic acids·2025
Same author

Viral circular RNA-encoded protein, ceVP28, divulges an antiviral response in invertebrates.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Unveiling the impact of shrimp piRNAs on WSSV infection and immune modulation.

Fish & shellfish immunology·2025
Same author

Participation of shrimp pva-miR-166 in hemocyte homeostasis by modulating apoptosis-related gene <i>PvProsaposin</i> during white spot syndrome virus infection.

Journal of virology·2024
Same journal

Waterborne diseases and climate change.

Nature reviews. Microbiology·2026
Same journal

Climate adaptation and biodiversity shape West Nile virus risk in cities.

Nature reviews. Microbiology·2026
Same journal

Climate factors and evolution drive cholera surges in Dhaka.

Nature reviews. Microbiology·2026
Same journal

Climate change boosts Salmonella antimicrobial resistance.

Nature reviews. Microbiology·2026
Same journal

Reframing risk assessment for malaria elimination in a changing climate.

Nature reviews. Microbiology·2026
Same journal

Bacterial vesicles protect the membrane during polymyxin stress.

Nature reviews. Microbiology·2026
See all related articles

Cellular microRNAs (miRNAs) influence gene activity and viral pathogenesis. Viruses encode or hijack these miRNAs, impacting viral infection and latency.

Area of Science:

  • Molecular Biology
  • Virology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression in a cell-type and tissue-specific manner.
  • Cellular miRNAs play roles in fundamental biological processes such as cell growth and differentiation.
  • Viruses exhibit distinct tissue tropisms, suggesting potential interactions with host cellular factors like miRNAs.

Purpose of the Study:

  • To review recent findings on the interplay between viral and cellular microRNAs.
  • To explore how microRNAs modulate viral pathogenesis and the viral life cycle.

Main Methods:

  • Literature review of recent studies on viral microRNAs and host-pathogen interactions.
  • Analysis of mechanisms by which viruses encode or utilize cellular miRNAs.

Related Experiment Videos

  • Examination of the role of miRNAs in viral infection and latency.

    • Main Results:

    • Some vertebrate viruses encode their own miRNAs.
    • Viruses can subvert or manipulate host cellular miRNAs to their advantage.
    • These viral and hijacked cellular miRNAs are involved in both the acute infectious and the chronic latent phases of viral infections.

    Conclusions:

    • MicroRNAs are significant players in the complex relationship between viruses and their hosts.
    • Understanding viral miRNA interactions offers insights into viral pathogenesis and potential therapeutic strategies.