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Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
Published on: September 26, 2016
Calculation of the Entropy of Lattice Polymer Models from Monte Carlo Trajectories
Ronald P White1, Jason Funt, Hagai Meirovitch
1Department of Computational Biology, University of Pittsburgh School of Medicine, Biomedical Science Tower, 1058w, Pittsburgh PA 15261.
Abstract:
While lattice models are used extensively for macromolecules (synthetic polymers proteins, etc), calculation of the absolute entropy, S, and the free energy, F, from a given Monte Carlo (MC) trajectory is not straightforward. Recently we have developed the hypothetical scanning MC (HSMC) method for calculating S and F of fluids. Here we extend HSMC to self-avoiding walks on a square lattice and discuss its wide applicability to complex polymer lattice models. HSMC is independent of existing techniques and thus constitutes an independent research tool; it provides rigorous upper and lower bounds for F, which can be obtained from a very small sample and even from a single chain conformation.
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