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Melanocortin 5 receptor and ocular immunity

A W Taylor1, N Kitaichi, D Biros

  • 1Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. awtaylor@vision.eri.harvard.edu

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|August 18, 2006
PubMed
Summary

Melanocortin 5 receptor (MC5r) expression is crucial for protecting the retina from autoimmune inflammation and inducing regulatory T cells. MC5r deficiency leads to severe retinal damage and impaired immune responses during experimental autoimmune uveoretinitis.

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