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Updated: Aug 6, 2026

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
Published on: July 12, 2021
THE SCN2A gene is not a likely candidate for familial mesial temporal lobe epilepsy
Cláudia Vianna Maurer-Morelli1, Rodrigo Secolin, Rafael Breglio Marchesini
1Department of Medical Genetics, Universidade Estadual de Campinas-UNICAMP, Tessália Vieira de Camargo, 126, Cidade Universitária Zeferino Vaz, Campinas CEP 13084-971, SP, Brazil.
Abstract:
A transgenic mouse model carrying a mutation in the Scn2a gene showed chronic focal seizures associated with extensive cell loss and gliosis in the hippocampus, a similar phenotype found in familial mesial temporal lobe epilepsy (FMTLE). Our objective was to test whether the human homolog of the Scn2a gene is responsible for hippocampal abnormalities in FMTLE by linkage analysis. We conclusively ruled out the SCN2A gene as candidate in FMTLE.
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