Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel membranes and surface modification able to activate specific cellular responses.

Loredana De Bartolo1, Sabrina Morelli, Antonella Piscioneri

  • 1Institute on Membrane Technology, National Research Council of Italy, ITM-CNR, c/o University of Calabria, via P. Bucci, cubo 17/C, 1-87030 Rende (CS), Italy. l.debartolo@itm.cnr.it

Biomolecular Engineering
|August 18, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

VH3810109 Efficacy, Safety, Pharmacokinetics, and Incidence of Antidrug Antibodies in Adults With HIV-1 Naive to Antiretroviral Therapy: BANNER Study Results.

The Journal of infectious diseases·2025
Same author

Mesoporous Silica-Loaded PCL-CHT Hybrid Membranes for Skin Regeneration.

ACS applied materials & interfaces·2025
Same author

VH3810109 (N6LS) broadly neutralizing antibody safety, pharmacokinetics, and anti-drug antibody incidence in adults without HIV: phase 1 SPAN study results.

Antimicrobial agents and chemotherapy·2025
Same author

Methacrylated chitosan/jellyfish collagen membranes as cell instructive platforms for liver tissue engineering.

International journal of biological macromolecules·2024
Same author

Optimization of Membrane Condenser Process with PTFE Hollow Fiber Membrane.

Membranes·2024
Same author

Extracellular vesicles selective capture by peptide-functionalized hollow fiber membranes.

Journal of colloid and interface science·2024

Researchers developed novel polymeric biomaterials and surface modification strategies to improve cell-biomaterial interactions. Modified membranes effectively supported human liver cell maintenance and function, showing promise for biohybrid systems.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Optimizing cell-biomaterial interactions is crucial for advanced biohybrid systems.
  • Novel polymeric biomaterials and surface modification techniques are needed for improved in vivo and in vitro applications.

Purpose of the Study:

  • To synthesize novel semipermeable membranes from polyetheretherketone and polyurethane blends.
  • To modify polyethersulfone membranes using plasma polymerization and RGD peptide immobilization.
  • To evaluate the performance of these modified membranes in supporting human liver cell function.

Main Methods:

  • Synthesis of semipermeable membranes from modified polyetheretherketone/polyurethane blends.
  • Surface modification of polyethersulfone membranes via plasma polymerization of acrylic acid.

Related Experiment Videos

  • Immobilization of arginine-glycine-aspartic acid (RGD) peptide using a hydrophilic spacer arm.
  • Assessment of primary human hepatocyte function (albumin production, protein secretion, drug metabolism).

    • Main Results:

    • The novel polyetheretherketone/polyurethane membranes supported long-term human liver cell maintenance and differentiation.
    • Surface-modified polyethersulfone membranes demonstrated enhanced liver cell function.
    • Evaluations included albumin production, protein secretion, and drug biotransformation capabilities of hepatocytes.

    Conclusions:

    • Developed polymeric biomaterials and surface modification strategies significantly enhance cell-biomaterial interactions.
    • Modified membranes show potential for long-term maintenance and functional expression of human liver cells in biohybrid systems.
    • These advancements are critical for optimizing biohybrid systems in regenerative medicine and drug development.