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Updated: Aug 6, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Estrogen receptor pathway: resistance to endocrine therapy and new therapeutic approaches
1Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. bmoy@partners.org
Abstract:
Endocrine therapy is widely accepted as the most important treatment for all patients with hormone receptor-positive breast cancer. However, despite the positive effect of endocrine therapy on clinical outcome, resistance to these drugs inevitably develops. This article reviews the problem of resistance to hormonal therapy and addresses potential approaches to overcome intrinsic or acquired mechanisms of resistance.
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