Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.1K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.1K
Structure and Function of Platelets01:18

Structure and Function of Platelets

4.2K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.2K
Introduction to Hemostasis01:05

Introduction to Hemostasis

15.4K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
15.4K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

14.2K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
14.2K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

9.7K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
9.7K
Coagulation01:09

Coagulation

11.3K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
11.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ANKRD26-related thrombocytopenia 2 with a baseline increase in blasts: implications for clinical surveillance.

Blood·2025
Same author

Platelet Pathophysiology: Unexpected New Research Directions.

Seminars in thrombosis and hemostasis·2024
Same author

Dysregulation of platelet serotonin, 14-3-3, and GPIX in sudden infant death syndrome.

Scientific reports·2024
Same author

Platelet Physiology.

Seminars in thrombosis and hemostasis·2024
Same author

Management strategies and prognosis of patients ineligible for transcatheter mitral valve replacement.

Cardiovascular revascularization medicine : including molecular interventions·2024
Same author

Critical Analysis of Thrombocytopenia Associated With Glycoprotein IIb/IIIa Inhibitors and Potential Role of Zalunfiban, a Novel Small Molecule Glycoprotein Inhibitor, in Understanding the Mechanism(s).

Journal of the American Heart Association·2023

Related Experiment Video

Updated: Mar 3, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.2K

Platelet activation and progression to complications.

Dean J Kereiakes1, Alan D Michelson

  • 1Heart Center of Greater Cincinnati and Lindner Center at Christ Hospital, Cincinnati, Ohio, USA.

Reviews in Cardiovascular Medicine
|August 18, 2006
PubMed
Summary

Platelet function is crucial for blood clotting and may be abnormal in acute coronary syndromes. Assessing platelet function before percutaneous coronary intervention (PCI) helps predict adverse events, with higher inhibition levels improving outcomes.

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K
Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

12.3K

Related Experiment Videos

Last Updated: Mar 3, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.2K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K
Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

12.3K

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Pharmacology

Background:

  • Platelets play a key role in hemostasis by localizing, amplifying, and sustaining coagulation at injury sites.
  • Procoagulant platelet-derived microparticles are released by activated platelets.
  • Abnormalities in platelet size and function are observed in acute coronary syndromes and after percutaneous coronary intervention (PCI).

Purpose of the Study:

  • To evaluate the significance of platelet function assessment prior to PCI.
  • To understand the relationship between platelet inhibition and clinical benefit from glycoprotein IIb-IIIa inhibitors during PCI.
  • To explore the potential of combined antiplatelet therapies for enhanced thrombosis inhibition.

Main Methods:

  • Platelet functional assessment was utilized as a predictive tool for adverse clinical events post-PCI.
  • Clinical trials involving glycoprotein IIb-IIIa inhibitors as adjunctive PCI pharmacotherapy were analyzed.
  • The correlation between the magnitude of platelet inhibition and observed clinical benefit was examined.

Main Results:

  • Platelet functional assessment before PCI predicts subsequent adverse clinical events.
  • The degree of clinical benefit from glycoprotein IIb-IIIa inhibitors correlates with the level of platelet inhibition achieved.
  • Optimal periprocedural outcomes generally necessitate high levels of platelet inhibition.

Conclusions:

  • Platelet function assessment is a valuable predictor of outcomes following PCI.
  • Achieving substantial platelet inhibition is essential for optimal periprocedural results in PCI.
  • Combined antiplatelet therapies may offer synergistic inhibition of platelet-mediated thrombosis, potentially improving patient outcomes.