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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

[Rotavirus gastroenteritis]

Biljana Vuletić, Slobodan Obradović, Andjelka Stojkovic-Andjelković

    Srpski Arhiv Za Celokupno Lekarstvo
    |August 19, 2006
    PubMed

    Insights

    Rotavirus causes severe diarrhea in young children globally, leading to nearly one million deaths annually. This research highlights viruses as a significant cause of acute diarrheal diseases in children under five.

    Area of Science:

    • Virology
    • Pediatrics
    • Epidemiology

    Context:

    • Rotavirus is a leading cause of severe diarrheal diseases in children under two years old worldwide.
    • Annual global mortality from rotavirus-induced dehydration approaches one million, disproportionately affecting developing nations.
    • Acute diarrheal diseases pose a significant public health challenge in pediatric populations.

    Purpose:

    • To investigate the role of viral agents, specifically Rotavirus, in acute diarrheal diseases among children in Kragujevac and surrounding areas.
    • To determine the etiological contribution of viruses to pediatric acute diarrheal diseases in the studied region.
    • To analyze the incidence and characteristics of viral gastroenteritis in young children.

    Summary:

    • This 18-month study (December 1998-May 2000) analyzed 124 children (0-5 years) with acute diarrhea at HMC "Kragujevac".
    • Viruses were identified as the causative agents in 27% of the cases, underscoring their importance in pediatric diarrheal diseases.
    • Rotavirus, a member of the Reoviridae family, is a globally prevalent pathogen transmitted orally, affecting the upper small intestine.

    Impact:

    • The findings emphasize the significant role of viral infections in pediatric diarrheal diseases within the studied region.
    • Understanding the prevalence of rotavirus infections supports the need for targeted prevention strategies.
    • High morbidity and mortality rates associated with rotavirus necessitate active immunization programs, particularly in developing countries.

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