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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Worldwide trends in lung cancer pathology

Edward Gabrielson1

  • 1Department of Pathology, Cancer Center, Johns Hopkins University School of Medicine, 1550 East Orleans Street, Baltimore, MD 21231, USA. egabriel@jhmi.edu

Respirology (Carlton, Vic.)
|August 19, 2006
PubMed

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...