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Immunoglobulin uptake and processing by Schistosoma mansoni.
C Thors1, T S Jokiranta, T Meri
1Swedish Institute for Infectious Disease Control (SMI), Solna, Sweden.
Parasite Immunology
|August 19, 2006
Summary
Schistosoma mansoni worms absorb host immunoglobulins via Fc-receptors and enteric digestion. These immunoglobulins are processed into distinct granules within specialized organelles, likely in the excretory system.
Area of Science:
- Parasitology
- Immunology
- Cell Biology
Background:
- Intravascular Schistosoma mansoni worms interact with host immunoglobulins.
- The mechanism of immunoglobulin processing by these parasites remains unclear.
Purpose of the Study:
- To investigate the morphological processes involved in host immunoglobulin uptake and processing by intravascular Schistosoma mansoni.
Main Methods:
- Morphological analysis using immunogold staining.
- In vivo studies with radiolabelled immunoglobulins.
Main Results:
- Host immunoglobulins were localized in the parasite's oesophagus and as granular staining on the surface and subtegument.
- Organelle-like structures, termed 'discoid or elongate bodies', were identified containing immunoglobulins.
- In vivo studies confirmed immunoglobulin uptake and localization as fine strands perpendicular to the parasite surface.
Conclusions:
- Schistosoma mansoni utilizes both enteric digestion and Fc-receptor-mediated mechanisms for immunoglobulin uptake.
- Immunoglobulins are processed within specialized organelles ('elongate bodies') and potentially the excretory system.