Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A rapid screening tool for fatigue impact in multiple sclerosis.

Daphne Kos1, Guy Nagels, Marie B D'Hooghe

  • 1Department of Rehabilitation Research, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Daphne.Kos@vub.ac.be

BMC Neurology
|August 19, 2006
PubMed
Summary

A new visual analogue scale (VAS_1) effectively screens for fatigue impact in multiple sclerosis (MS). This rapid tool demonstrates good sensitivity and specificity for identifying severe fatigue in MS patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spinal cord reserve is associated with multi-dimensional clinical resilience in multiple sclerosis.

Journal of neurology·2026
Same author

Deconfounded, quantitative microbiome profiling identifies robust multiple sclerosis markers and clinical covariate associations.

Gut microbes·2026
Same author

The relationship between objective and subjective cognitive performance and clinical and MRI disease burden in early multiple sclerosis.

Scientific reports·2026
Same author

Quantitative EEG in post-stroke delirium: Spectral and Functional Connectivity Analyses in a Case-Control Study.

Translational stroke research·2026
Same author

Transcranial alternating current stimulation at 10 Hz promotes oligodendrogenesis and reduces g-ratio after cuprizone-induced demyelination.

iScience·2026
Same author

Real-world federated learning for brain imaging scientists.

Frontiers in digital health·2026

Area of Science:

  • Neurology
  • Psychometrics
  • Rehabilitation

Background:

  • Fatigue significantly impacts daily functioning in multiple sclerosis (MS) patients.
  • Efficient tools are needed for clinicians and researchers to assess fatigue levels in MS.
  • This study validates a rapid screening instrument for fatigue impact in MS.

Purpose of the Study:

  • To evaluate the psychometric properties of three visual analogue scales (VAS) for assessing fatigue impact in MS.
  • To determine the reliability, validity, and accuracy of these VAS scales.
  • To identify the most effective VAS scale for rapid fatigue screening in MS.

Main Methods:

  • Developed three VAS scales for fatigue impact assessment.
  • Administered VAS scales, Fatigue Severity Scale (FSS), Modified Fatigue Impact Scale (MFIS), and Guy's Neurological Disability Scale (GNDS) to 62 MS patients and 24 controls.

Related Experiment Videos

  • Assessed reproducibility using intraclass correlations (ICC) and validity via correlation coefficients and ROC analysis.

    • Main Results:

    • VAS scales demonstrated moderate reliability (ICC 0.68-0.69) and low to moderate correlations with FSS, MFIS, and GNDS.
    • All VAS scales differentiated between MS patients and controls.
    • VAS_1 showed high sensitivity (76-81%) and specificity (72-77%) in classifying individuals with significant fatigue, particularly at a cut-off of 59.

    Conclusions:

    • The VAS for the impact of fatigue on daily life (VAS_1) is a reliable, valid, and useful tool for rapid fatigue screening in MS.
    • A VAS_1 cut-off score of 59 effectively identifies individuals with severe fatigue impacting daily life.
    • While useful for screening, comprehensive fatigue assessment is recommended in clinical practice.