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Airway complications in CHARGE association
B F Asher1, T J McGill, L Kaplan
1Department of Otolaryngology, St Louis (Mo) Children's Hospital.
Archives of Otolaryngology--Head & Neck Surgery
|May 1, 1990
Summary
Children with CHARGE association are prone to airway instability. Respiratory arrests in these patients can worsen developmental delay, suggesting cerebral hypoxia plays a role. Early tracheotomy is recommended to protect the central nervous system.
Area of Science:
- Pediatric Medicine
- Genetics
- Neurology
Background:
- CHARGE association is a complex genetic disorder affecting multiple systems.
- Airway instability is a known complication in CHARGE association.
- Developmental delay is common in affected children.
Purpose of the Study:
- To investigate the association between catastrophic airway events and developmental delay in patients with CHARGE association.
- To determine the impact of respiratory arrests on neurodevelopmental outcomes.
Main Methods:
- Retrospective chart analysis of 16 patients with CHARGE association at The Children's Hospital, Boston.
- Categorization of patients based on the occurrence of respiratory arrests.
- Assessment of developmental delay severity in relation to airway events.
Main Results:
- Nine out of 16 patients experienced at least one respiratory arrest.
- Fourteen patients exhibited some degree of developmental delay.
- Developmental delay was most severe in patients who suffered respiratory arrests, indicating potential cerebral hypoxia.
Conclusions:
- Children with CHARGE association have a significant propensity for airway instability.
- Cerebral hypoxia resulting from airway events may contribute to developmental delay.
- Early tracheotomy is recommended over choanal atresia repair to safeguard neurodevelopment in these patients.