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Association between inflammation, lipid and hemostatic factors in patients with stable angina

José D Sagastagoitia1, Yolanda Sáez, Marta Vacas

  • 1Servicio de Cardiología, Hospital de Basurto, Departamento Medicina, Universidad del País Vasco UPV/EHU, Bilbao, Spain.

Thrombosis Research
|August 19, 2006
PubMed

Insights

Inflammation, indicated by C-reactive protein, correlates with prothrombotic factors like fibrinogen and D-dimer in stable angina patients. Apolipoprotein A1 shows an inverse association, suggesting anti-inflammatory properties.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Chemistry
  • Atherosclerosis Research

Background:

  • Atherosclerosis involves dyslipidemia, thrombosis, and inflammation.
  • Understanding the interplay between these factors is crucial for managing stable angina.

Purpose of the Study:

  • To investigate the association between inflammation, lipid profiles, and thrombotic markers in patients with stable angina.
  • To explore the relationship between C-reactive protein, lipid parameters, and coagulation factors.

Main Methods:

  • Study included 295 patients (mean age 65.69 years) with stable angina.
  • Measured levels of C-reactive protein, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, lipoprotein(a), apolipoproteins A1 and B100, fibrinogen, and D-dimer.
  • Utilized correlation and multivariate analyses to assess associations.

Main Results:

  • Elevated C-reactive protein correlated positively with fibrinogen and D-dimer.
  • High C-reactive protein showed an inverse correlation with HDL cholesterol and apolipoprotein A1.
  • Fibrinogen and D-dimer were independently associated with high C-reactive protein; apolipoprotein A1 was inversely associated.

Conclusions:

  • Confirms a link between prothrombotic states and inflammation in stable angina.
  • Suggests apolipoprotein A1 may possess anti-inflammatory effects.
  • Highlights the complex relationship between lipids, thrombosis, and inflammation in cardiovascular disease.
Abstract

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