Cyclic variation of T1 in the myocardium at 3 T

Standard methods of longitudinal relaxation (T1) measurements in the heart produce only one T1 map of the myocardium, usually at the end diastole (ED). In this article, we investigated the feasibility of using a dual flip angle fast gradient echo technique in the steady state to generate a movie of T1 maps in the myocardium during the cardiac cycle. The effects of nonideal slice profile and transient steady state on the T1 measurements were evaluated by Bloch simulations. Based on these results, we introduce a linear correction to the measured T1 values, which was validated by phantom experiments. In vivo T1 cine maps in healthy volunteers show 70+/-7% drop in T1 from the ED to the end systole in the septum and a 43+/-13% drop in the left ventricular lateral wall. With further improvements, this technique could be used to assess the myocardial blood volume changes during the cardiac cycle.