Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Control of acid secretion.

M L Schubert1, R D Shamburek

  • 1Medical College of Virginia, Richmond.

Gastroenterology Clinics of North America
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

Understanding gastric acid secretion pathways, including neural, hormonal, and paracrine stimulants, is key to developing new drugs. This research details the complex signaling mechanisms and identifies targets for effective acid secretion inhibitors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance characteristics of optical coherence tomography in assessment of Barrett's esophagus and esophageal cancer: systematic review.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2017
Same author

Brain-gut and appetite regulating hormones in the control of gastric secretion and mucosal protection.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2008
Same author

Stomach and duodenum.

Current opinion in gastroenterology·2006
Same author

Gastric secretion.

Current opinion in gastroenterology·2006
Same author

Gastric secretion.

Current opinion in gastroenterology·2006
Same author

Stomach and duodenum.

Current opinion in gastroenterology·2006
Same journal

Living Donor Intestinal and Liver Transplantation.

Gastroenterology clinics of North America·2026
Same journal

Living Abdominal Organ Donation: A Plan B That Saves Lives.

Gastroenterology clinics of North America·2026
Same journal

Long-Term Outcomes of Living Liver Donors.

Gastroenterology clinics of North America·2026
Same journal

Perioperative Management of Living Liver Donor Patients.

Gastroenterology clinics of North America·2026
Same journal

Living Donor Liver Transplantation for Colorectal Cancer Liver Metastasis.

Gastroenterology clinics of North America·2026
Same journal

Living Donor Liver Graft in Adult Populations: Donor Selection and Workup.

Gastroenterology clinics of North America·2026
See all related articles

Area of Science:

  • Gastroenterology and Physiology
  • Molecular Biology and Pharmacology

Background:

  • Parietal cells secrete gastric acid, a process regulated by multiple signaling pathways.
  • Neural (acetylcholine), hormonal (gastrin), and paracrine (histamine) stimulants interact with specific receptors on parietal cells.
  • Complex intracellular signal transduction pathways modulate the activity of the H+/K+-ATPase proton pump.

Purpose of the Study:

  • To elucidate the detailed mechanisms of gastric acid secretion regulation.
  • To identify the signal transduction pathways involved in stimulation and inhibition of acid secretion.
  • To explore the role of neural and paracrine regulation in gastric and acid secretion.

Main Methods:

  • Identification of receptors for secretory stimulants (acetylcholine, gastrin, histamine, somatostatin, prostaglandin E) on parietal cells.

Related Experiment Videos

  • Analysis of signal transduction pathways, including adenylate cyclase activity and cytosolic calcium levels.
  • Investigation of intramural neural and paracrine pathways regulating gastrin and acid secretion.

    • Main Results:

    • Histamine stimulates via adenylate cyclase; acetylcholine and gastrin stimulate via increased cytosolic calcium.
    • Synergistic effects between stimulants suggest post-receptor pathway interactions.
    • Somatostatin and prostaglandin E inhibit acid secretion by reducing adenylate cyclase activity.
    • Cholinergic neurons and bombesin stimulate gastrin secretion, while somatostatin inhibits it.
    • Cholinergic neurons directly and indirectly stimulate acid secretion, partly by inhibiting somatostatin.
    • Intraluminal acidification stimulates somatostatin, which inhibits acid secretion (feedback).

    Conclusions:

    • A comprehensive understanding of gastric acid secretion pathways has been achieved.
    • Knowledge of these pathways has led to the development of novel acid secretion inhibitors.
    • Targeting stimulatory receptors, inhibitory receptors, or the H+/K+-ATPase offers therapeutic strategies.