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Substance P increases rat aortic albumin permeability.
R A Markle1, M L Boyd, V H Coryell
1Department of Biological Sciences, Northern Arizona University, Flagstaff 86011-5640.
Life Sciences
|January 1, 1990
Summary
Substance P (SP), a neuropeptide, was found to increase aortic permeability to albumin in rats at specific concentrations. These findings suggest SP influences vascular barrier function.
Area of Science:
- Physiology
- Pharmacology
- Vascular Biology
Background:
- Vascular permeability is crucial for regulating substance exchange between blood and tissues.
- The role of neuropeptides like substance P (SP) in modulating vascular barrier function is an area of ongoing research.
Purpose of the Study:
- To investigate the effect of exogenous substance P (SP) on rat aortic permeability to plasma albumin.
Main Methods:
- In vivo experiments using fluorescein-labeled bovine serum albumin as a tracer.
- Intravenous infusion of varying concentrations of SP in rats.
- Measurement of normalized albumin mass transfer rates across the aortic wall.
Main Results:
- A significant increase in aortic albumin transfer was observed with SP administration at 7.4 pmol/kg/min and 0.74 pmol/kg/min.
- Lower and higher concentrations of SP did not produce significant changes in albumin transfer rates.
- These results indicate a dose-dependent effect of SP on aortic permeability.
Conclusions:
- Exogenous substance P (SP) can enhance rat aortic permeability to plasma albumin.
- The effect is observed at specific picomolar concentrations, suggesting a targeted mechanism.
- SP may play a role in regulating vascular barrier function in the aorta.