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[Parathyroid carcinoma].

Aleksandar Filipović1, Ivan Paunović, Dragutin Savjak

  • 1Klinicki centar Crne Gore, Hirurska klinika, Podgorica, Crna Gora. a.filipovic@cg.yu

Vojnosanitetski Pregled
|August 22, 2006
PubMed
Summary

Parathyroid carcinoma, a rare endocrine malignancy, often presents as primary hyperparathyroidism. Surgical en bloc resection offers the best treatment for this rare cancer.

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Area of Science:

  • Endocrinology
  • Oncology
  • Surgical Pathology

Background:

  • Parathyroid carcinoma is an exceptionally rare endocrine malignancy, accounting for less than 1% of primary hyperparathyroidism cases.
  • Early recognition and surgical intervention are crucial for managing this unusual cancer.

Observation:

  • A case report details a 30-year-old patient with parathyroid carcinoma, primary hyperparathyroidism, and recurrent nephrocalcinosis.
  • Symptoms included marked hypercalcemia, low phosphorus, elevated parathyroid hormone, anorexia, weakness, back pain, and depression.
  • Preoperative ultrasonography identified a 2 cm left upper parathyroid tumor with mixed solid and cystic areas.

Findings:

  • Histopathological evaluation confirmed parathyroid carcinoma following en bloc tumor resection.
  • The patient experienced no disease recurrence over a three-year follow-up, with normalized serum calcium and parathyroid hormone levels.

Implications:

  • Parathyroid carcinoma is a rare but significant cause of primary hyperparathyroidism.
  • Accurate preoperative diagnosis remains challenging.
  • Radical en bloc resection is the recommended surgical approach for parathyroid carcinoma.

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