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Recombinant factor VIIa in paediatric bleeding disorders--a 2006 review

P Mathew1, G Young

  • 1Department of Pediatrics, University of New Mexico, Albuquerque, NM 87131-0001, and Children's Hospital of Orange County, Orange, CA, USA. pmathew@salud.unm.edu

Haemophilia : the Official Journal of the World Federation of Hemophilia
|August 22, 2006
PubMed

Recombinant factor VIIa (rFVIIa) has been used in haemophilia bleeding since its introduction in 1996. It has been found to be safe and effective in the majority of patients with haemophilia who have developed inhibitors. There is increasing use of rFVIIa in many off-label bleeding conditions, but there is a paucity of randomized studies regarding the use of rFVIIa in children. This review will attempt to address and summarize the studies focusing on the role of rFVIIa in both haemophilia and non-haemophilia bleeding conditions in children. rFVIIa has been administered as both bolus and continuous infusions, and at varying doses. Furthermore, adverse events have not reportedly increased in children despite growing experience with its use in the paediatric population.

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