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Primary colorectal lymphomas.

M T C Wong1, K W Eu

  • 1Department of Colorectal Surgery, Singapore General Hospital, Singapore.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
|August 22, 2006
PubMed
Summary
This summary is machine-generated.

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Primary colorectal lymphoma is a rare cancer predominantly affecting males, often diagnosed at advanced stages. Multimodality treatment including surgery and chemotherapy shows promising survival rates for this uncommon malignancy.

Area of Science:

  • Gastroenterology
  • Oncology
  • Surgical Pathology

Background:

  • Primary colorectal lymphoma is a rare malignancy, accounting for a small fraction of gastrointestinal lymphomas and colorectal cancers.
  • It predominantly affects males aged 50-70, often presenting with nonspecific symptoms leading to delayed diagnosis and advanced disease.

Purpose of the Study:

  • To review the experience in managing primary colorectal lymphomas over a 10-year period.
  • To analyze patient demographics, clinical presentation, diagnostic methods, treatment approaches, and outcomes.

Main Methods:

  • Retrospective review of 14 primary colorectal lymphoma cases diagnosed between 1989 and 1999.
  • Inclusion based on Dawson criteria for primary intestinal lymphoma.
  • Classification using WHO system and staging via modified Ann Arbor system.

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Main Results:

  • 14 cases identified (0.44% of colorectal malignancies), predominantly in males (13/14) with a mean age of 61.
  • Common presentations included abdominal pain, anorexia, weight loss, and abdominal mass, with the cecum being the most frequent site.
  • All cases were non-Hodgkin's B-cell lymphomas, mostly diffuse large B-cell lymphoma, diagnosed via laparotomy with evidence of spread.
  • Surgical resection followed by adjuvant chemotherapy was the primary treatment; over half of patients remain alive with no recurrence.

Conclusions:

  • Primary colorectal lymphoma is rare, affecting males in their 6th-7th decades, typically presenting late with advanced disease.
  • Histologically, it is usually an intermediate-grade B-cell lymphoma.
  • Multimodality treatment involving surgery and chemotherapy offers potential for long-term survival.