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Related Experiment Videos

Ion concentrations from hip implants.

Alene Sargeant1, Tarum Goswami, M Swank

  • 1Department of Biological Sciences, Ohio Northern University, 525 S. Main Street, Ada, OH 45810, USA.

Journal of Surgical Orthopaedic Advances
|August 22, 2006
PubMed
Summary

Metal implants from hip replacements release ions, potentially causing adverse health effects. This review compiles data on ion concentrations and their physiological impacts.

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Area of Science:

  • Biomaterials Science
  • Toxicology
  • Orthopedic Surgery

Background:

  • Total hip joint arthroplasty (THA) is increasingly common, with metallic implants used in hip, knee, and spine prostheses.
  • These metallic implants can release ions into the body during articulation.
  • Elevated ion concentrations are linked to adverse physiological effects.

Purpose of the Study:

  • To compile and review reference levels of metal ion concentrations in body fluids and tissues.
  • To present ion concentrations released from various metallic alloys used in joint prostheses.
  • To review clinical and laboratory data on metal ion effects.

Main Methods:

  • Literature review of studies on metal ion concentrations in patients with joint prostheses.
  • Compilation of reference levels for ions in biological samples.
  • Review of laboratory data on the physiological effects of metals.

Main Results:

  • Presents reference levels for ion concentrations in body fluids and tissues.
  • Details ion concentrations released from specific alloys (cobalt, chromium, nickel, molybdenum, titanium, aluminum, vanadium).
  • Summarizes clinical findings and laboratory data on metal ion toxicity.

Conclusions:

  • Metal ion release from joint prostheses is a significant concern.
  • Understanding ion concentrations and their physiological effects is crucial for patient safety.
  • Further research is needed to establish safe limits and mitigate risks.

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