Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A citric acid-based hydroxyapatite composite for orthopedic implants.

Hongjin Qiu1, Jian Yang, Pradeep Kodali

  • 1Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, E310 Evanston, IL 60208, USA.

Biomaterials
|August 22, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Healing cascades and infections in wounds monitored using a wearable sensor of gaseous flux.

bioRxiv : the preprint server for biology·2026
Same author

Simultaneous regeneration of skin and bone in full-thickness cranial composite defects.

bioRxiv : the preprint server for biology·2026
Same author

Sex-Specific Outcomes in Adolescent ACL Reconstruction: A Propensity-Matched Cohort Study.

Orthopaedic journal of sports medicine·2026
Same author

A Double-Blind Randomized Comparison Trial of Postoperative Pain in Patients Undergoing Total Shoulder Arthroplasty Who Receive Interscalene Blocks with near Equipotent Doses of Plain 0.5% Bupivacaine vs. Liposomal Bupivacaine.

Journal of clinical medicine·2026
Same author

The Sport Publication Observational Research Tool (SPORT): An Objective Tool to Score the Methodological Quality of Observational Clinical Sports Medicine Research.

Orthopaedic journal of sports medicine·2026
Same author

The association of sarcopenia with surgical outcomes and complications following reverse total shoulder arthroplasty: a matched cohort study with comparative analysis against anatomic total shoulder arthroplasty.

JSES international·2026

This study introduces a new bioceramic-elastomer composite for orthopedic devices. The poly(1,8-octanediol-citrate) (POC) and hydroxyapatite (HA) composite shows promising mechanical properties, biocompatibility, and osteoconductivity for bone screws.

Area of Science:

  • Biomaterials Science
  • Orthopedic Engineering
  • Polymer Chemistry

Background:

  • Bioceramic-elastomer composites offer potential for orthopedic applications.
  • Developing suitable materials for tissue fixation devices is crucial in orthopedic surgery.
  • Poly(diol citrates) are biodegradable elastomers with tunable properties.

Purpose of the Study:

  • To develop and characterize novel bioceramic-elastomer composites for orthopedic surgery.
  • To assess the feasibility of fabricating tissue fixation devices using these composites.
  • To evaluate the mechanical properties, degradation, mineralization, and biocompatibility of POC-HA composites.

Main Methods:

  • Processing of bioceramic microparticles and poly(diol citrates) into composites.

Related Experiment Videos

  • Fabrication of composites using machining and molding techniques.
  • Mechanical testing, in vitro degradation studies, simulated body fluid immersion, osteoblast adhesion assays, and in vivo implantation in rabbit knees.

    • Main Results:

    • POC-HA composites with varying HA content (40-65wt.%) exhibited mechanical properties suitable for tissue fixation devices.
    • The 65wt.% HA composite showed the slowest degradation rate (8-12wt.% weight loss at 20 weeks).
    • Composites underwent mineralization in simulated body fluid, forming calcium phosphate, supported osteoblast adhesion, and demonstrated biocompatibility in vivo.

    Conclusions:

    • The synthesized POC-HA composite is easy, inexpensive, and suitable for fabricating potentially osteoconductive bone screws.
    • The material's mechanical properties, biocompatibility, and osteoconductive potential make it a promising candidate for orthopedic applications.
    • Further development could lead to advanced tissue fixation devices for orthopedic surgery.