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Effects of pirenzepine on CCK-stimulated canine pancreatic exocrine secretion
G M Salido1, M Z Gil, J A Pariente
1Department of Physiology, Faculty of Veterinary Science, University of Extremadura, Caceres, Spain.
General Pharmacology
|January 1, 1990
Abstract:
1. The effects of the anticholinergic compound pirenzepine on pancreatic secretion stimulated by intravenous infusions of increasing doses of CCK (0.025-0.4 Ivy Dog Unit/kg/min) were investigated in fasting anaesthetized dogs. 2. Pirenzepine (0.75 mg/kg i.v.) slightly reduced the increases in the pancreatic juice secretion evoked by CCK. 3. Similar results were obtained with others anticholinergic compounds as atropine (3 mg/kg i.v.) and hexametonium (5 mg/kg i.v.).