Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myocardial dysfunction with increased ventricular compliance in volume overload hypertrophy.

Laercio Martins De Stefano1, Luiz Shiguero Matsubara, Beatriz Bojikian Matsubara

  • 1Department of Clinical Medicine, Botucatu School of Medicine-UNESP, Brazil.

European Journal of Heart Failure
|August 22, 2006
PubMed
Summary

Volume overload induced myocardial hypertrophy in rats led to systolic and diastolic dysfunction, characterized by increased ventricular compliance. These findings explain the compensatory phase before heart failure develops.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of a Supervised Twelve-Week Combined Physical Training Program in Heart Failure Patients: A Randomized Trial.

Cardiology research and practice·2019
Same author

Aldosterone is associated with left ventricular hypertrophy in hemodialysis patients.

Therapeutic advances in cardiovascular disease·2016
Same author

Spironolactone is secure and reduces left ventricular hypertrophy in hemodialysis patients.

Therapeutic advances in cardiovascular disease·2015
Same author

Acute doxorubicin-induced cardiotoxicity is associated with matrix metalloproteinase-2 alterations in rats.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology·2015
Same author

Antidepressant treatment decreases daily salt intake and prevents heart dysfunction following subchronic aortic regurgitation in rats.

Physiology & behavior·2015
Same author

Association between sleep quality and quality of life in nursing professionals working rotating shifts.

Revista de saude publica·2014

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Remodeling
  • Heart Failure Pathophysiology

Background:

  • Myocardial hypertrophy is a complex adaptation to increased cardiac workload.
  • Understanding the functional consequences of volume overload is crucial for managing heart failure.

Purpose of the Study:

  • To investigate systolic and diastolic cardiac function in rats with experimentally induced volume overload myocardial hypertrophy.
  • To characterize the hemodynamic changes associated with this model of cardiac adaptation.

Main Methods:

  • Volume overload myocardial hypertrophy was induced in Wistar rats via infrarenal arteriovenous fistula (AVF) creation.
  • Hemodynamic parameters were assessed using isolated heart studies (Langendorff preparation) eight weeks post-surgery.
  • Ventricular weights, pressure-volume relationships, and compliance were analyzed and compared to a SHAM-operated control group.

Related Experiment Videos

Main Results:

  • AVF rats exhibited significantly increased left and right ventricular weights and chamber dilation.
  • Systolic dysfunction was evidenced by decreased +dP/dt and end-systolic pressure-volume relation.
  • Diastolic dysfunction was indicated by increased ventricular compliance (DeltaV(25)) despite preserved myocardial passive stiffness.

Conclusions:

  • Volume overload-induced hypertrophy results in significant myocardial systolic and diastolic dysfunction.
  • Increased ventricular compliance is a key feature of this compensatory phase.
  • These hemodynamic alterations provide insight into the progression towards congestive heart failure.