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Related Experiment Videos

Pathogen-derived immunomodulatory molecules: future immunotherapeutics?

Padraic G Fallon1, Antonio Alcami

  • 1School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland, and Department of Medicine, Addenbrooke's Hospital, Cambridge, UK. pfallon@tcd.ie

Trends in Immunology
|August 22, 2006
PubMed
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Pathogen molecules that regulate immunity offer potential as new immunotherapeutics. This review explores pathogen immunomodulatory molecules (IM) for treating human diseases by modulating immune responses.

Area of Science:

  • Immunology
  • Microbiology
  • Biotechnology

Background:

  • Pathogen-host co-evolution has optimized molecules that modulate innate and adaptive immunity.
  • These molecules, termed immunomodulatory molecules (IM), present opportunities for therapeutic development.
  • Research in identifying and utilizing these IM is rapidly advancing.

Purpose of the Study:

  • To review the application of pathogen-derived immunomodulatory molecules (IM).
  • To highlight IM produced as recombinant proteins with diverse modulatory functions.
  • To discuss the potential of these IM in managing detrimental immune responses in human diseases.

Main Methods:

  • Literature review focusing on pathogen immunomodulatory molecules (IM).
  • Analysis of studies involving recombinant protein production of IM.

Related Experiment Videos

  • Examination of research on the therapeutic potential of IM in human diseases.

    • Main Results:

    • Pathogen IM, produced recombinantly, exhibit various immune-modulating activities.
    • These molecules have demonstrated potential in preclinical and clinical investigations.
    • Diverse strategies exist for utilizing IM to target specific immune pathways.

    Conclusions:

    • Pathogen immunomodulatory molecules (IM) are promising candidates for novel immunotherapeutics.
    • Recombinant production facilitates the use of IM for therapeutic interventions.
    • Targeting undesirable immune responses with pathogen IM offers a new avenue for treating human diseases.