Related Experiment Video
Updated: Aug 6, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
Potent inhibition of human Hepatitis B virus replication by a host factor Vps4
Pong Kian Chua1, Min-Hui Lin, Chiaho Shih
1Institute for Human Infections and Immunology, Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.
Abstract:
Vps4 is a host factor known to be involved in cellular vacuolar protein sorting. We report here that HBV replication and secretion can be significantly inhibited by Vps4 dominant negative, ATPase-defective, mutants K173Q and E228Q. In contrast, wild-type Vps4 at low dose can inhibit HBV replication more effectively in human hepatoblastoma cell line HepG2, than in human hepatoma cell line Huh7. To our knowledge, this is the first demonstration of an anti-HBV potential of dominant negative mutants of a protein sorting host factor Vps4.
Related Concept Videos
Hepatitis
Inhibitors Of Virion Release
Inhibitors of Viral Protein Synthesis
Inhibitors of Virion Maturation and Assembly
Antiviral Nucleoside Inhibitors
Viruses with RNA Genomes

