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An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challenge
Yun Zhou1, Ming-Kai Chen, Christopher J Endres
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St., JHOC room 3245, Baltimore, MD 21287, USA. yunzhou@jhmi.edu
Neuroimage
|August 22, 2006
Summary
The extended simplified reference tissue model (ESRTM) accurately quantifies dynamic positron emission tomography (PET) changes in binding potential during amphetamine challenges, improving upon equilibrium methods that underestimate results.
Area of Science:
- Neuroscience
- Pharmacology
- Medical Imaging
Background:
- Dynamic PET analysis with amphetamine challenge relies on steady-state assumptions.
- Violating steady-state assumptions can lead to inaccurate estimation of binding potential changes.
Purpose of the Study:
- To develop and validate an extended simplified reference tissue model (ESRTM) for improved PET kinetic modeling.
- To address limitations of equilibrium analysis in dynamic PET studies with amphetamine challenge.
Main Methods:
- Derived and applied the ESRTM to dynamic [11C]raclopride PET data in non-human primates.
- Administered varying doses of amphetamine to assess dose-dependent binding potential changes.
- Utilized computer simulations to further characterize ESRTM performance.
Main Results:
- ESRTM provided more accurate DeltaBP% estimates compared to equilibrium methods, which underestimated results.
- Demonstrated a linear relationship between DeltaBP% and log-dose of amphetamine in baboons (R2=0.96).
- ESRTM results were consistent with previous [11C]raclopride PET studies.
Conclusions:
- The ESRTM is a robust kinetic modeling approach for dynamic PET.
- ESRTM is recommended for quantifying PET data during acute amphetamine stimulation.
