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Related Experiment Videos

Potential adverse events with biologic response modifiers.

James S W Kong1, Suzanne S Teuber, M Eric Gershwin

  • 1Division of Rheumatology, Allergy, and Clinical Immunology, Department of Internal Medicine, University of California, Davis, California 95616, USA.

Autoimmunity Reviews
|August 22, 2006
PubMed
Summary

Biologic response modifiers, including cytokines and antibodies, treat immune-mediated diseases but can cause adverse reactions. This review examines the safety profiles of commonly used biologic agents.

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Area of Science:

  • Immunology and Pharmacology
  • Biotechnology and Therapeutics

Background:

  • Biologic response modifiers are increasingly used for immune-mediated diseases.
  • These agents include recombinant cytokines and engineered antibodies.
  • Adverse reactions can be expected or unexpected.

Purpose of the Study:

  • To review the adverse event profiles of select biologic response modifiers.
  • To focus on agents with substantial available data and common use in rheumatology, allergy/immunology, and dermatology.

Main Methods:

  • Review of case studies and randomized trials.
  • Analysis of adverse event data for biologic response modifiers.

Main Results:

  • Biologic response modifiers have demonstrated potential toxicities.

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  • Adverse reactions vary and require careful monitoring.

    • Conclusions:

    • Understanding the adverse event profiles of biologic response modifiers is crucial for patient safety.
    • This review provides insights into the safety of commonly used biologic agents.