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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Mesothelioma research as a social issue
1The Mesothelioma Applied Research Foundation, Santa Barbara, California 93190-1840, USA. c-hahn@marf.org
Abstract:
From a social perspective, a number of factors may explain why mesothelioma research has tended to be an "orphan." The disease has a relatively low incidence compared to other cancers, the average age of mesothelioma patients is relatively high, the disease is expected to decline "on its own," and the disease has long been considered intractable to therapy. However, there are persuasive counterpoints to these factors. Additionally, other aspects of the mesothelioma tragedy persuasively justify societal investment in mesothelioma research. Social justice is among the strongest of these reasons, but paradoxically, it also significantly impedes progress. Mesothelioma patients' contribution to society is another strong justification, although also not without problems. Finally, optimal utilization of resources provides a very pragmatic, and potentially very forceful, justification for increased societal investment in mesothelioma research.
Insights
Research into mesothelioma, a rare cancer, is underfunded due to low incidence and perceived intractability. However, social justice and resource optimization argue for increased investment in mesothelioma research.
Area of Science:
- Oncology
- Public Health
- Social Sciences
Background:
- Mesothelioma research is considered an "orphan" due to several factors: low disease incidence, older patient demographics, expected natural decline, and historical treatment intractability.
- Despite these challenges, compelling arguments exist for increased societal investment in mesothelioma research.
- These arguments include social justice considerations, the societal contributions of mesothelioma patients, and the pragmatic need for optimal resource utilization.
Purpose of the Study:
- To analyze the social factors contributing to the underfunding of mesothelioma research.
- To present counterarguments and justifications for increased societal investment in mesothelioma research.
Main Methods:
- Qualitative analysis of social and ethical factors influencing research funding.
- Review of existing literature on mesothelioma epidemiology, patient demographics, and treatment outcomes.
- Ethical and economic arguments for research investment.
Main Results:
- Identified low incidence, patient age, expected disease decline, and therapeutic challenges as reasons for research neglect.
- Highlighted social justice and patient societal contributions as ethical imperatives for research.
- Presented resource optimization as a pragmatic justification for increased investment.
Conclusions:
- Societal investment in mesothelioma research is ethically and pragmatically justified.
- Addressing the "orphan" status of mesothelioma research requires overcoming social and logistical barriers.
- Increased funding is crucial for advancing understanding and treatment of this rare cancer.
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