Related Experiment Video

Updated: Aug 6, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
06:44

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct

June X Zou1, Zhenyu Zhong, Xu-Bao Shi

  • 1UC Davis Cancer Center/Basic Sciences, Department of Biochemistry & Molecular Medicine, University of California at Davis, School of Medicine, Sacramento, California, USA. jxzou@ucdavis.edu

The Prostate
|August 22, 2006
PubMed
Abstract

Insights

Androgen receptor (AR) and ACTR co-factor are crucial for prostate cancer cell growth and tumor development. They may drive resistance to androgen ablation therapy by regulating cell cycle genes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Co-factor ACTR is frequently overexpressed and amplified in various tumors.
  • The precise role of ACTR in prostate cancer (CaP) remains largely unknown.

Purpose of the Study:

  • To investigate the functional role of ACTR and androgen receptor (AR) in prostate cancer progression.
  • To elucidate the mechanism by which ACTR and AR influence cell proliferation and gene expression in CaP.

Main Methods:

  • Analysis of ACTR and AR depletion effects on cell proliferation and gene expression.
  • Utilized a panel of androgen-dependent and -independent CaP cell lines.
  • Employed CWR22 xenograft models for in vivo studies.

Main Results:

  • ACTR and AR are essential for the proliferation of both androgen-dependent and -independent CaP cells, as well as tumor growth.
  • AR depletion affected expression of cyclins D1, B, and cdc2, while ACTR depletion impacted cyclin E and cdk2.
  • Both AR and ACTR are recruited to target gene promoters for activation in an androgen-independent manner.

Conclusions:

  • AR and ACTR play significant roles in prostate cancer.
  • These co-factors may contribute to androgen ablation resistance.
  • Their involvement in controlling key cell cycle gene expression is critical for CaP progression.

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