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Direct action of human granulocyte colony-stimulating factor on mature human neutrophils: flow-cytometric analysis
1Cancer Center, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Research Communications in Chemical Pathology and Pharmacology
|February 1, 1990
Abstract:
The direct effects of human granulocyte colony-stimulating factor (G-CSF) on mature neutrophils in vitro were studied using flow cytometry. G-CSF increased the neutrophil forward scatter without recruitment of side scatter, as assessed by flow cytometry. This indicates that G-CSF acts on neutrophils directly and induces the activation of mature neutrophils without degranulation of primary granules.